of diabetes and inday
August 17th, 2008 by janmihaelvaldez
The unsurpassed elucidation of
the physiology and pathophysiology of diabetes mellitus from Inday, the montemayor family’s chambermaid.
Your illness is a complex metabolic derangement is characterized by
a grossly abnormal usage of fuel. the level of insulin is
inappropriately low while that of glucagon is too high relative to the
needs of the body. As in starvation, glucose utilization in your
illness is poor, but glucose is actually present in excessive amounts.
Sir, its starvation amidst plenty.
Therefore, sir, there is an inhibition in the pathways of both
glycolysis and glycogenesis. The liver attempts to generate glucose
from 2 equivalents of PYRUVATE, which is catalyzed by pyruvate
carboxylase, and uses up 2ATPs and converts it to ADP. The product
OXALOACETATE is converted to PHOSPHOENOL PYRUVATE, in a GTP mediated
reaction between the substrate and the enzyme PEP Carboxylase. PEP is
then converted to 3-PHOSPHOGLYCERATE, 1,3 BIPHOSPHOGLYCERATE, FRUCTOSE
1,6-BIPHOSPHATE, FRUCTOSE-6-PHOSPHATE, each in succession though the
enzyme phosphoglycerate kinase, then spontaneous oxidation by NADH,
then enzyme Fructose 1,6-biphosphatase, respectively. The precursor to
Glucose is now produced. The product GLUCOSE 6-PHOSPHATE underwent a
dephosphorylation reaction by the enzyme Glucose 6-phosphatase to
produce GLUCOSE, otherwise known as your Blood Sugar.
Sir, that explains the heightened level of glucose in your
bloodstream. This pathway further increases that glucose level in a
well-fed state.
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on August 19th, 2008 at 1:49 am
..hahaha isa lng masasabi ko.. JOHN LLOYD please.. =D
on August 26th, 2008 at 1:13 am
biogesic? sumakit ang ulo mo ate mhelai? nyahahaha. ako din eh